A very high-speed wireless access of 100 Mb/s to 1 Gb/s is required for fourth-generation mobile communications systems. However, for such high-speed data transmissions, the channel is severely frequency-selective due to the presence of many interfering paths with different time delays. A promising wireless access technique that can overcome the channel frequencyselectivity and even take advantage of this

selectivity to improve the transmission performance is CDMA. There may be two approaches in CDMA technique: direct sequence CDMA and multicarrier CDMA. A lot of attention is paid to MC-CDMA. However, recently it has been revealed that DS-CDMA can achieve good performance comparable to MC-CDMA if proper frequency domain equalization is adopted. This article discusses their similarities and performances. A major transmission mode in 4G systems will be packet-based. Automatic repeat request combined with channel coding is a very important technique. Recent research activity on this technique is also introduced.